LAI risperidone has also been compared with zuclopenthixol in patients with schizophrenia and comorbid substance abuse in a randomized, open-label, 6-month study that reported a 34% reduction in the Positive and Negative Syndrome scale total score, an effect size that is almost identical to that observed in the CGI overall severity score here (i.e., a 36% reduction) [39]
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