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Brcic L, Iva B, Mario S, Novinscak T, Sikiric P, Seiwerth S

This metal-binding arrangement influences the physicochemical properties of the complex and has made GHK-Cu a widely studied model system for investigating copper coordination chemistry, ligand-metal interactions, metallopeptide stability, and copper-dependent signaling mechanisms

While collagen provides the physical structure, glutathione protects that structure from being broken down by free radicals

More importantly, PKM2 can translocate into the nucleus, where it regulates the transcription of metabolic genes such as HIF-1, LDHA, and GLUT1, thereby enhancing glycolysis, suppressing OXPHOS, and establishing a metabolic firewall against therapeutic stress [97]