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This highlights the importance of individualizing treatment and monitoring symptoms carefully

Support for this idea comes from the observation that tobacco overexpressing both -ECS and GSH-S had an ameliorated phenotype compared to tobacco expressing the first enzyme alone (Creissen et al., 1999)

Earlier Predictive Value: During early acute liver injury, GR activity rises significantly, with its peak appearing earlier than that of transaminases (ALT, AST), providing a more timely window for clinical intervention [4] Major liver disease guidelines from the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) emphasize the need to detect early hepatocyte stress and dysfunction, particularly in conditions like drug-induced liver injury [5,6]

H., Kim S., Lee N., Lee J., Yu S