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A more recent randomized, double-blind, placebo-controlled study in 30 patients with type 2 diabetes found that intravenous infusion of 600 mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate (63)

Full names for all the enzymes and substrates are given in Additional File 1

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However, exposure of compounds like NR and NMN to serum results in their low stability and degradation in the blood 68,124