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These include the individual's current health status, metabolism, weight loss goals, and any underlying medical conditions

[2] However, later studies failed to demonstrate a sufficient lipolytic effect

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J

When NNMT activity is high, the body may become less efficient at using stored fat for energy, which can contribute to stubborn weight, low energy, and frustrating plateaus