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To tolerate fluctuations in water levels and prevent collapse it should have a vent fitted with a hydrophobic air filter to prevent microbial contamination from outside air

One of the major challenges is caused by unsuccessful treatments due to the existence of the blood brain barrier (BBB)

62 These molecular events typically include those related to stress responses within the cell, such as DNA repair, epigenetic regulation, protein homeostasis, metabolic regulation, and the modulation of the extracellular microenvironment

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