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Given the complex moonlighting nature of A, passive immunotherapies aimed at diminishing A in the brain would appear to be at best a partial response to treating AD, that in light of a new meta-analysis appears to actually be associated with accelerated loss of brain volume (Alves et al., 2023), a disturbing finding that confirms previously voiced concerns over this approach (Hilund-Carlsen and Alavi, 2021

Genetic, physiological, and dietary modulators are all involved in the regulation of CPT1A (Figure 5)

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