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In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]

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Exosomes derived from CAFs in PDAC do not exhibit gemcitabine resistance, however, CAFs promote chemotherapy resistance in PDAC cells by secreting exosomes and maintaining signal exchange with PDAC cells after gemcitabine treatment

Glutathione is one of the major antioxidants that can tackle and neutralize free radicals that cause oxidative stress in the body which would otherwise damage cells