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Since the inaugural successful cryopreservation of a human oocyte in 1986, technological advancements have provided women with a form of fertility insurance. Nevertheless, oxidative stress exerts a profound influence on oocyte quality and the outcomes of cryopreservation

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Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels