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Peripheral neurons and adipocytes seem to be significantly affected.25-28 The dideoxynucleosides stavudine and didanosine have been shown to produce significant depletion of mitochondrial DNA in both of these tissues.29,30 The cohort we chose to study consisted of HIV-infected patients exhibiting neurologic toxicity from either stavudine and/or didanosine so that we might examine the effects of micronutrient supplementation on HIV disease progression and on one clinical manifestation of mitochondrial toxicity: distal symmetrical polyneuropathy (DSP)

#2: Non-Steroidal Androgen Receptor Blockers RU58841 Aside from not being derived from hormones, the major difference between steroidal vs

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Its equivalent phrase, ADME (absorption, metabolism, disposal, and excretion), is used in the pharmaceutical sector as a comparable term [169]