TRPR sets some requirements relating to the labelling and presentation of certain vaping products, including: child-resistant and tamper-evident packaging mandatory health warnings on the front and back of the packet a ban on misleading health claims information on ingredients and nicotine content a leaflet inside the pack with usage instructions, health risks and any necessary warnings a ban on packaging that suggests that a particular vaping product is less harmful than other vaping products The General Product Safety Regulations 2005, and the General Product Safety Regulation (EU) 2023/988 as it applies in Northern Ireland, sets requirements that non-nicotine vapes and nicotine products like nicotine pouches must be safe for consumption
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Among these, N-nitrosodimethylamine (NDMA) is a potent hepatocarcinogen that induces DNA alkylation, oxidative stress, and promotes liver fibrosis, ultimately facilitating HCC development [26]
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