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11 Foods high in sugar, gluten, refined grains, dairy, trans fats, and other additives are associated with triggering inflammation in the body and should be kept to a minimum

To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed

In contrast, inducing mitochondrial damage in normal FLSs can promote NF-B pathway activation and ROS production and increase the secretion of inflammatory factors (116)

(4) Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ