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Archeological evidence in Mexico suggests the plants may have been cultivated as far back as 1400 BCE, and it is likely the plant was used throughout much of the North American continent

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Just some of the health effects include: high blood pressure caused by constricted blood vessels increased risk of stroke and heart attack from higher blood pressure and damaged blood vessels increased risk of lung diseases Skin damage from reduced blood flow [2] Because it is so addictive, nicotine also poses a risk to your health by encouraging people to continue smoking and subsequently consuming all the other harmful chemicals in cigarettes