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Chronic selenium deficiency is associated with lethargy, dizziness, motor weakness and paresthesias, and an excess risk of amyotrophic lateral sclerosis
In terms of specific regulatory effects, the protective role of mitophagy is mainly reflected in a state of moderate activation: when cells are subjected to mild stress and mitochondria undergo local damage, mitophagy can specifically recognize and clear damaged, depolarized mitochondria, effectively reducing the abnormal release of ROS and the cytoplasmic leakage of mtDNA
Notably, ferroptotic susceptibility is determined not only by iron overload but also by the lipid ratio and the capacity of antioxidant defense systems
Saudi Sidr honey was demonstrated to arrest the G0/G1 phase in colorectal (HCT-116), breast (MCF-7) and lung (A-549) cancer cells, shortening the S, G2, and M phases (92)
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