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10.1038/s41598-021-89442-7 203 WangP.LiB.CaiG.HuangM.JiangL.PuJ.et al (2014a)

Given that gemcitabine induces ferroptosis as part of its anticancer mechanism, combining ferroptosis-inducing therapies with gemcitabine has emerged as a promising strategy to overcome drug resistance

This leads to a form of cerebral folate deficiency (CFD) , where the brain has low levels of 5-methyltetrahydrofolate (5-MTHF) , the active folate form crucial for neurotransmitter synthesis, DNA methylation, and myelin formation