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This shows how NO and ROS signaling from stromal cells creates a pro-tumor environment, reinforcing the toxohormone concept, where signals from one cell type promote cancer growth in another (129, 132)

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This is an illustrative research schedule, not a prescription

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Studies referenced: SURMOUNT-4 (Jastreboff, JAMA 2024), STEP 1 extension (Wilding, Diabetes Obes Metab 2022), STEP 4 (Rubino, JAMA 2021), West et al

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