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Bridging this translational gap will require rigorous clinical validation, improved delivery strategies, and careful regulatory frameworks to ensure safe and effective integration of peptide therapeutics into musculoskeletal medicine

35,36 EMERGING AGENTS IN THE PIPELINE Several late-stage IBTs are expected to expand the weight-management landscape in 2026 or later, including CagriSema, a combination of semaglutide and cagrilintide (a long-acting amylin analogue regulating appetite and glucose)

E-J Chem 7:S299S313 Silva B, Costa F, Neves IC, Tavares T (2015) Psychiatric pharmaceuticals as emerging contaminants in wastewater

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