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Although the highest growth was recorded at pH 6 after 72 h (1.616), the strain also showed high growth under alkaline conditions at pH 810 (0.7371.364)

The compounds tested included dermorphin, [D-Arg]dermorphin, and a series of truncated [D-Arg]dermorphin fragments, namely [D-Arg]dermorphin(16), (15), (14), (13), and (12)

Heatmaps showing z-score normalized median expression levels were created using R package pheatmap, all correlations were performed in R using the packages ggcorrplot, principal component analyses were performed using MMIs for each sample using the stats package in R

ERK1/2 activation upregulates collagen gene expression and promotes cell proliferation critical for fibroblast proliferation, while p38 MAPK inhibition reduces inflammatory response