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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

Fig.1 Structure of AOD-9604 With obesity and metabolic disorders on the rise, peptides like AOD-9604 are attracting attention for their potential role in weight loss and fat metabolism

These differential effects of insulin on glucose uptake vs