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Additionally, redox reactions are regulated by the oxidoreductases Trx and Grx, which are specific targets of signal transduction pathways associated with the stress response (Jimnez et al., 2024)

Increase gradually only if needed

Microglia are initially activated to stage 1 DAM, which are characterized by a downregulation of homeostatic microglial genes including p2ry12 and cx3cr1 , and an upregulation of genes including trem2 , tyrobp and apoe

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