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In the application note Comparison of thioredoxin activity in cortical neuron and glial cells using a BMG LABTECH microplate reader a thioredoxin system that contains sulfhydryl groups protected cells against H 2 O 2 -induced cell death and its inhibition promoted oxidative stress, while thioredoxin-overexpressing mice displayed less oxidative brain damage following ischemia and lived longer

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J Endocrinol Invest (2014) 37(12):114353