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They do not replace the need for proper rehabilitation

Investigations of the Pseudomonas ketosteroid isomerase based on deuterium and tritium labeling of reactants provided evidence for direct and stereospecific diaxial proton transfer from the 4 to the 6 position (Talalay, 1965)

After reconstitution: Store at 28C and use within 1428 days

The reason is entirely about gastrointestinal tolerability nausea, diarrhea, and vomiting were clearly dose-dependent and concentrated in the weeks right after each step-up