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In a prospective study of Fontan patients, elevated baseline serum GDF-15 levels were independently associated with impaired functional status and an increased risk of adverse outcomes, including hospitalization, heart transplant listing, and all-cause mortality

Bakaeen FG, Jaroszewski DE, Rice DC, Walsh GL, Vaporciyan AA, Swisher SG , Benjamin R, Blackmon S, Reardon MJ

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Reports have indicated that Vitamin C and Vitamin E can directly neutralize ROS, further enhancing the cell's antioxidant defense capabilities [415, 416]