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It has been reported that STAT3 can directly bind to NF-B and facilitate its nuclear translocation and target gene expression, suggesting that STAT3 is involved in the constitutive activation of NF-B (39)

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Metformin Trade Names: Glucophage, Glucophage XR Drug Class: oral hypoglycemic, biguanide Mechanism of Action: via activation of AMP-activated protein kinase (AMPK)(see Figure 1)

Theanine Theanine, an amino acid found in green tea, promotes relaxation without causing drowsiness