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Regarding how iron overload and imbalance in ROS homeostasis affect, IE in patients with -thal, the current research suggests that iron overload leads to an imbalance in ROS homeostasis, which in turn causes oxidative damage to erythroid cells

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Demonstrated proof-of-concept for the dual agonist approach Phase 1b/2a (SC): Up to 24% weight loss at 36 weeks with doses up to 60 mg