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Taking these drawbacks into consideration, the prodrugs of EGCG analogs were synthesized with the compounds identified as 2a and 4a having lower susceptibility to be metabolized or inhibited by COMT and having an amplified antiproliferative, antiangiogenic, and antifibrotic effect in HuLM ( Scutellaria barbata D

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Contrarily, in all BPC 157-treated rats, from the very beginning, the lesion was markedly smaller (half the size, given the very large lesion in the controls), with less edema, necrosis of muscle fibers, and acute inflammation with foci of abscessation