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31 Over time, a third phase of stabilization, erosion and ulceration of the colonic mucosal epithelium may be accompanied by bleeding and the secretion of large amounts of mucus, with relatively stable symptoms that require long-term treatment and management to prevent recurrence

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135 Therefore, the canonical Wnt signalling pathway is considered the main mechanism of RSPO2 regulation, and it has been proposed that it may be a more precise bone mass regulator