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Ethical concerns also arise when considering their use for non-therapeutic purposes, particularly in professional athletic competitions

If such a vicious cycle of glutamate excitotoxicity, oxidative stress, and mitochondrial dysfunction does indeed underpin ME/CFS pathology, it may not be clear where exactly the root problem lies

After the lyophilization process, it forms a tiny, compact puck or a light dusting of powder at the bottom of the vial, which can be hard to see

Researchers prevent this by immediately deproteinizing samples with acidic solutions such as metaphosphoric acid (MPA) or perchloric acid (PCA) and processing all materials on ice