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Changes in Levels of the Antioxidant Glutathione in Brain and Blood Across the Age Span of Healthy Adults: A Systematic Review. NeuroImage: Clinical 40: 103503

In addition, SHMT2 depletion has been shown to induce mitochondrial respiratory chain deficiency by reducing basal respiration and respiratory capacity, decreasing NAD + /NADH ratios, and lowering the expression levels of respiratory complex I, IV, and V proteins [93]

H19 -DMR is an imprinted region that coordinately controls the expression of important regulators of cell growth and differentiation H19 and IGF2 genes

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