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Discussion Numerous studies have documented that HFD in rats induces insulin resistance, while low-dose STZ administration selectively impairs insulin secretion, replicating the progressive nature of T2DM

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This is primarily because they not only act on the intended sites but may also interact with other biomolecules, causing non-specific effects or side effects, such as diminishing the effectiveness of other therapeutic drugs or directly harming healthy tissues [124]

That distinction is the single biggest source of confusion in the field, and we dedicate an entire reference to it: Thymosin Beta-4 vs TB-500 are they the same peptide