The S2 products displayed antibiotic resistance genes including vancomycin resistance associated response regulator ( vraR , K07694), small multi-drug resistance pump ( emrE , K03297), macrolide transport system ATP binding/permease protein ( macA , K05685), fosmidomycin resistance protein ( tsr , K08223), and penicillin-binding protein activator ( lpoB , K07337) (Figure 7 and Supplementary Table 6)
& Leisch, F
[222] By the early 17th century, this allure fueled its mercilessly laborious cultivation as a cash crop in the Virginia colonies, where John Rolfe's introduction in 1612 rescued Jamestown from economic collapse and famine, transforming it into a prosperous export hub with over 20,000 pounds shipped by 1619 and laying the groundwork for transatlantic trade
While it wasnt terrible, the construction could have been better