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Furthermore, exposure to all of these EDCs can impact the expression and enzymatic activity of DNA methyltransferases, potentially interfering with enzymes like aromatase ( The potential impact of EDCs on thyroid hormone regulation in children is of particular concern as thyroid hormones play a crucial role in the growth and central nervous system development, and control the overall physiological homeostasis ( In recent years, there has been increasing evidence of the effects of EDCs exposure on thyroid hormone levels from animal experiments and epidemiological studies
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MTHFR mutations cause low Glutathione, causing more toxicity and higher oxidative stress leading to chronic neurological and metabolic conditions
They are usually mild and temporary
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