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The first time was when the study initially appeared

Day 1: 500mg or 1000mg NAD IV (2.5-5 hrs) Day 4: 100mg NAD SQ Day 6: 100mg NAD SQ Daily: 250mg NR/NMN in the morning Week 8 NR/NMN has a dose-response curve but also hits a plateau

Singh JA et al (2012): 2012 Update of the 2008 American College of Rheumatology Recommendations for the Use of Disease-Modifying Antirheumatic Drugs and Biologic Agents in the Treatment of Rheumatoid Arthritis