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Notably, ketoconazole abolished low-density lipoprotein (LDL)-induced reductase activity at submicromolar concentrations in various mammalian cell lines (IEC-6 cells, skin fibroblasts, HepG2, and Chinese hamster ovary cells), suggesting a potential application in cardiovascular disease [99]

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Analyses of national data on adults have shown that poor sleep is associated with increased concentrations of inflammatory markers and poor physical and mental health, particularly cardiovascular disorders and migraine ( Sleep 36: 671-679, 2013)