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This allows -catenin to accumulate in the cytoplasm and translocate into the nucleus where it binds to T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) transcription factors and recruits co-activators such as cyclic AMP response element-binding protein-binding protein (CBP) or p300

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This BsAb demonstrates potent and selective cytotoxicity in vitro and effective treatment of tumors in the cell line xenograft model 20

Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of foxp3+ Regulatory T cells