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In numerous controlled studies, methylphenidate palliated several behavioral ASD features including impulsivity, attention deficiency, and hyperactivity, but it correspondingly exhibited some initial adverse effects such as aggression, anorexia, and increased wakefulness (insomnia) (Handen et al., 2000

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[34] Neurological symptoms: sensory or motor deficiencies (absent reflexes, diminished vibration or soft touch sensation) and subacute combined degeneration of the spinal cord