Recent research has shown that ferroptosis may contribute to the development of complications associated with diabetes mellitus, including kidney disease [8], osteoporosis [9], encephalopathy [10], cardiomyopathy [11], retinopathy [12], and MASLD [13, 14]
Markers of microbial dysbiosis, such as shifts in the Firmicutes/Bacteroidetes ratio, reduction in butyrate-producing species, and increased LPS levels, may serve as early indicators of circadian-gut axis dysfunction 260
DSIP also modulates the hypothalamicpituitaryadrenal (HPA) axis, lowering nighttime cortisol spikes and reducing stressrelated arousal, which contributes to more stable circadian rhythms Peptide therapy for sleep has an excellent safety profile when administered under qualified medical supervision, with minimal side effects and no dependency risk
Microglia promote remyelination independent of their role in clearing myelin debris