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However, the observed phenotype in these mice was again not a simple ramification of mucosal barrier deregulation, but was the result of a conglomerate of defects in epithelial homeostasis, including epithelial cell apoptosis and barrier function irregularities

This means the same dose injected in a damaged site may absorb differently than the same dose in healthy tissue, making your dosage chart unreliable

Starting without deficiency correction data or clinical indication increases cost without evidence of benefit