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Moreover, given that multiple antagonists of the endothelin system already exist in the market for the treatment of pulmonary hypertension (bosentan, ambrisentan and macitentan), if ET-1 is proven to play a role in hyperoxia-induced kidney injury these medications could be repurposed to ameliorate kidney damage induced by high oxygen therapy

Peptides that increase BDNF levels While BDNF mimetics work by directly activating TrkB receptors, a separate category of peptides achieves cognitive benefits by increasing the brain natural production of BDNF

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