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Multicentre survey on compliance with growth hormone therapy: what can be improved

2023 Apr 21;18(4):756-771

This can happen anywhere along its path, but most often originates in the lower back (lumbar spine)

The histidine imidazole and the N-terminal amine and lysine side chain give GHK a high intrinsic affinity for copper(II), and as the free apo-peptide it has been studied in preclinical and in vitro research as a copper-binding ligand and as a signaling molecule implicated in extracellular-matrix remodeling, collagen and metalloproteinase regulation, and antioxidant and anti-inflammatory gene-expression pathways