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Another study measured exposure of harmful or potentially harmful ingredients in American Spirit smokers and in smokers of four other cigarette brands

We also focused on the nine toxicants (acetaldehyde, acrolein, benzo[a]pyrene, benzene, 1,3-butadiene, carbon monoxide (CO), formaldehyde, nitrosonornicotine (NNN) and 4-( N -nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) recommended for mandated reduction in cigarette smoke by the WHO Tobacco Product Regulation Group (WHO TobReg) which are also part of the HPHCs U.S.FDA list 53,54,55