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Before every administration a doctor carries out an assessment that rules out contraindications

Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model

We have included substrate activation (the Hill term on the right) and found that if we omitted this substrate activation then the cytochrome oxidase reactions did not produce enough NAPQI at high overdoses

J Biol Chem 279:61966203 Bartolini F, Andres-Delgado L, Qu X, Nik S, Ramalingam N, Kremer L, Alonso MA, Gundersen GG (2016) An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells