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Recent studies strongly support the notion that mitochondrial dysfunction and oxidative stress are the main drivers of OA pathogenesis 37

GAT-1 maintains the homeostasis of inhibitory neuronal microcircuits, and its functional or expression abnormalities are closely associated with the development of various neurological disorders, including autism, schizophrenia, and epilepsy ( 3.2.2 The Interaction between GABA and Its Receptors GABA signaling transduction is mediated by membrane-bound receptors, primarily involving two major types: GABAA and GABAB receptors

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