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Furthermore, AZI apparently reversed CS-induced Nrf2 suppression, and similar effects on airway epithelial barrier dysfunction were also found for Nrf2 agonist tert-butylhydroquinone and vitamin C

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However, after China joined the WTO in 2001, the industry faced the challenge of being small and weak compared to multinational tobacco companies, leading to the closure of small companies to support larger ones

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