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Prevention of lipoatrophy: In rare cases, repeated injection can lead to breakdown of subcutaneous fat (lipoatrophy), creating dimples

Because it does not suppress appetite, it can theoretically be combined with GLP-1 agonists to add a lipolytic component to the appetite suppression mechanism, though clinical data on this combination is lacking

The SURMOUNT-1 trial demonstrated 20.9% mean body weight reduction with tirzepatide 15mg weekly at 72 weeks, while preclinical 5-amino-1MQ studies showed visceral fat reduction independent of caloric restriction

Easy measuring: At ~23.3 mg/mL, 1 unit 233 mcg total on a U-100 syringe