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This step is crucial because certain peptides can interact with various drugs, especially glucocorticoids like prednisone and thyroid medications

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Similar to other neurotrophins, BDNF is first synthesized as a precursor protein, named pro-BDNF of 32 KDa, which is cleaved by different proteases to produce either the mature form of 14 KDa, or the truncated form of 28 KDa

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ALI is mainly caused by direct lung injuries, such as the inhalation of toxic substances, and indirect systemic diseases, including sepsis, bacterial pneumonia, and severe trauma [5]

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