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Zhang R, et al

first application at 30 min after surgery, last at 24 h before sacrifice

The findings that loss of claudin-7 expression induces sloughing of intestinal epithelial cells (claudin-7 KO mice), possibly by disrupting the complex between claudin-1, claudin-7 and 1-integrin, highlights the previously underappreciated roles of TJ proteins in cellmatrix interactions

Pickart and Margolinas 2018 analysis (PMID: 29986520) noted that the gene expression pattern produced by GHK is the mirror image of several cancer-associated gene signatures meaning GHK pushes expression in the opposite direction from what cancer cells typically exhibit