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In animal research, combined use shows improved results: Quicker formation of granulation tissue and wound closure Decreased edema and inflammation Better tendon-to-bone integration and ligament tensile load Systemic effects on the protection of distant organs, such as the liver and kidney in ischemia-reperfusion

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Baba S, Iwasa M, Higashi K, Minatoguchi S, Yamada Y, Kanamori H, Kawasaki M, Nishigaki K, Minatoguchi S (2017) Antidiabetic drug alogliptin protects the heart against ischemia-reperfusion injury through GLP-1 receptor-dependent and receptor-independent pathways involving nitric oxide production in rabbits