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It lacks electrolytes and is hypotonic, which can cause red blood cells to swell and rupture (hemolysis) if administered directly into the bloodstream

Pharmacokinetic studies confirm placental transfer in rodents, but no research has followed pregnancies to term after maternal peptide administration or assessed offspring for developmental abnormalities

Additionally, as research chemicals, these peptides are not regulated by the FDA, which raises questions about purity, dosage, and regulatory oversight

(1988) Effects of aminopeptidase inhibition on the half-lives of [125I]angiotensins in the cerebroventricles of the rat