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In some embodiments, the otic formulation or composition comprises about 0.05% by weight of the silicon dioxide

Researchers do this to equalise pressure and make drawing easier, but it introduces airborne contaminants and establishes a positive pressure differential that forces solution back through the needle tract on every subsequent draw

B12 deficiency can impair this process and prevent the use of storage form of folate when needed, resulting in functional folate deficiency

NAC has been previously shown to rescue DPI-induced cell death (53), are co-treated with certain ROS generators (54), or suffer from mitochondrial stress (55)